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The problem, often not discovered until late in life, is that when you look for things like love, meaning, motivation, it implies they are sitting behind a tree or under a rock. The most successful people recognize, that in life they create their own love, they manufacture their own meaning, they generate their own motivation. For me, I am driven by two main philosophies, know more today about the world than I knew yesterday. And along the way, lessen the suffering of others. You'd be surprised how far that gets you.

— You need to see him, John. You need to help him!
— Nope.
— He needs you!
— Somebody else. Not me. Not now.
— Now, you just listen to me for once in your stupid life. I know Mary's dead and I know your heart is broken. But if Sherlock Holmes dies too, who'll you have then? Because I'll tell you something, John Watson. You will not have me.
— Have you spoken to Mycroft, Molly, anyone?
— They don't matter, you do. Would you just see him, please, John? Or just take a look at him as a doctor? I know you'd change your mind if you did.
— Yeah, look. Okay. Maybe, if I get a chance.
— Do you promise?
— I'll try if I'm in the area.
— Promise me?
— I promise.
— Thank you.
[opens the trunk where Holmes is lying]