In the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
— I can't stop obsessing about this date. What do you think I should do?
— You should go ahead and thank your lucky stars you finally found a gal who's into same-sex relationships.
— My life is a mess.
— At least you're pretty.
— Pretty don't pay the rent.
— It does for my sister.
— Your sister's a prostitute?
— She's a model. Come on, we talked about thinking before we speak.