Two brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons and gods that roam the earth.
Just because you can do what you want doesn't mean that you get to do whatever you want!
— I left your flask in the back seat. The worst mascot in the world.
You know, I’ve… I’ve been here for a very long time. I remember many things. I remember being at a shoreline, watching a little gray fish heave itself up on the beach and an older brother saying, «Don’t step on that fish, Castiel. Big plans for that fish.» I remember the Tower of Babel… all 37 feet of it, which I suppose was impressive at the time. And when it fell, they howled «Divine Wrath». But come on. Dried dung can only be stacked so high. I remember Cain and Abel… David and Goliath… Sodom and Gomorrah. And, of course, I remember the most remarkable event… Remarkable because it never came to pass. It was averted by two boys… an old drunk… and a fallen Angel. The Grand Story. And we ripped up the ending and the rules… and Destiny… leaving nothing but freedom and choice. Which is all well and good, except… Well, what if I’ve made the wrong choice? How am I supposed to know? I’m getting ahead of myself. Let me tell you my story. Let me tell you everything.
His name is Misha!… Misha?! Misha? Jensen? …What's with names around here?
— That's for getting me killed.
— If it makes you feel better, we got him killed too.
— I'm cool with it!
— He's cool with it.
— Oh, you know, I thought you were supposed to be impressive. All you do is black out the room?
— And the eastern seaboard.
— I talked to Mr. Beetle's doctor. Turns out his incisions were sewn up with silk.
— That's weird?
— Yeah, nowadays it is, but silk used to be the suture of choice back in the early 19th-century. It was really problematic. Patients would get massive infections, the death rate was insane.
— Good times.
— Right. So, doctors, they had to do whatever they could to keep the infections from spreading. One way was maggots.
— Dude, I'm eating.
— It actually kind of worked because maggots, they eat the bad tissue and they leave good tissue. And get this: When they found our guy, his body cavity was stuffed full of maggots.
— Dude, I'm eating!
— I'm calmed down. Somebody stole my car.
— The 67' Impala, was that yours? Well, it was in a tow-away zone.
— No, it wasn't!
— It was when I finished with it.
— What?
— Nothing.
— Dean! What!?
— Dude, you full on had a girl up inside of you for like a week. That's pretty naughty.
— What's going on with everybody?
— I don't know.
— My neighbor… Mr. Rodgers, h-
— You've got a neighbor named Mr. Rodgers?
— Not anymore.